How Many Puffs of Vape Equal a Cigarette? One Juul pod contains the equivalent nicotine of 20 cigarettes a highly addictive amount. Today, some e cigs can contain more nicotine than *200 cigarettes.* Join us in sending a message to Vaping vs. Smoking: What's the Nicotine Equivalent? Curious about how vaping compares to smoking? Let's break it down! Disposable Vapes: A typical disposable vape with around 600 puffs can Juul, the vape device teens are getting hooked on, explained Vox