Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Glutathione pH responsive copper based nanoplatform for amplified chemodynamic therapy through synergistic cycling regeneration of reactive oxygen species and dual glutathione depletion ScienceDirect Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification Mast cell specific CysLT2 receptor signaling inhibits cysteinyl leukotriene dependent mast cell activation and type 2 allergic lung inflammation: Cell Reports