Hepatic transcriptome and proteome responses against diethyl maleate induced glutathione depletion in the rat Archives of Toxicology Springer Nature Link Full article: Role of glutathione in immunity and inflammation in the lung You can't out skincare internal depletion. Glutathione is one of the most important (and often overlooked) players in both skin clarity and overall wellness. When your body is overloaded, it shows up as: Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification