What is a coffee enema? And what is it used for? A coffee enema is just like a regular enema but with coffee instead of water. A coffee enema acts as Coffee Consumption and Oxidative Stress: A Review of Human Intervention Studies A coffee enema is a natural detoxification therapy in which brewed organic coffee is introduced into the colon through the rectum. This process stimulates the liver and gallbladder, promoting bile flow and PDF) Antioxidant effects after coffee enema or oral coffee consumption in healthy Thai male volunteers