HMP also known as the Pentose phosphate pathway. Consists of two irreversible oxidative rxs followed by a series of reversible A metabolic switch to the pentose phosphate pathway induces radiation resistance in pancreatic cancer Radiotherapy and Oncology Pentose Phosphate Pathway made simple. This pathway has two major jobs: Generate NADPH Produce ribose 5 phosphate NADPH protects cells from oxidative stress and supports fatty acid, cholesterol, steroid, nitric oxide, and respiratory burst Metabolism: The pentose phosphate pathway and G6PD deficiency (practice) Khan Academy