Acetaminophen, ethanol and other co ingestions ScienceDirect Let's talk Tylenol Paracetamol (acetaminophen) There are many side effects that most people don't realize. OTC does not mean it is side effect free, especially with chronic use. Even just 4 days of Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Chronic acetaminophen ingestion resulting in severe anion gap metabolic acidosis secondary to 5 oxoproline accumulation: an under diagnosed phenomenon BMJ Case Reports