The Gut Arterial Stiffness Axis: Is TMAO a Novel Target to Prevent Age Related Aortic Stiffening? Hypertension Intestinal microbiota metabolism of l carnitine, a nutrient in red meat, promotes atherosclerosis Nature Medicine The Role of Trimethylamine N Oxide as a Mediator of Cardiovascular Complications in Chronic Kidney Disease James Tomlins Trimethylamine N oxide (TMAO) is a small molecule produced in humans primarily by the gut liver axis and has become an important biomarker, and possible mediator, of cardiometabolic and renal disease. Dietary choline, phosphatidylcholine (
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l carnitine tmao Dietary bioactive ingredients to modulate the gut microbiota-derived metabolite TMAO. New opportunities for functional food development