5 Oxoprolinuria as a Cause for Metabolic Acidosis Renal Fellow Network Acetaminophen Pathway (toxic doses), Pharmacokinetics Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Reaching for Tylenol when baby is fussy? Here's some information worth knowing. A baby's liver isn't fully mature until around 2 years old Meaning their ability to process certain substances is still