Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen metabolism Acetaminophen Pathway (toxic doses), Pharmacokinetics Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums
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can you take glutathione with tylenol Silymarin prevents acetaminophen-induced hepatotoxicity via up-regulation of the glutathione conjugation capacity in mice