Methimazole induced hypothyroidism causes alteration of the REDOX environment, oxidative stress, and hepatic damage; events not caused by hypothyroidism itself Annals of Hepatology Is Topical Glutathione Effective for Thyroid Issues? Glutathione peroxidase 4 inhibition induces ferroptosis and mTOR pathway suppression in thyroid cancer Scientific Reports Levothyroxine (Synthroid, Tirosint, Levoxyl) is a medication for treating hypothyroidism (underactive thyroid), a condition that is more common in people with Down syndrome. Health care providers usually recommend taking levothyroxine with water