Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Implications of Altered Glutathione Metabolism in Aspirin Induced Oxidative Stress and Mitochondrial Dysfunction in HepG2 Cells PLOS One S Acetyl Glutathione 60 Capsules Glutathione and NAC Reduce the Severity of COVID 19