Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Targeting thioredoxin glutathione reductase as a potential antischistosomal drug target ScienceDirect PfK13 associated artemisinin resistance slows drug activation and enhances antioxidant defence, which can be overcome with sulforaphane bioRxiv RCSB PDB 6FMZ: Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 1,4 Bis(2 hydroxyethyl)piperazine