Cagrilintide is an amylin analogue that helps regulate appetite. In a randomized trial of over 3400 patients who were overweight or obese and had 1 weight related complication, individuals assigned to a combination Combined GLP 1 amylin analog bests monotherapy for HbA1c drop, weight loss in diabetes Cagrilintide (AM833) Long acting amylin analog. Beta cells make TWO hormones: insulin and amylin. Amylin slows stomach emptying and reduces appetite. Cagrilintide is a long acting synthetic amylin designed for once weekly dosing Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors Nature Communications