Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Hepatic Glutathione Synthesis: The Liver's Antioxidant Powerhouse Glutathione (GSH) is the most abundant intracellular antioxidantand the liver is its primary production site. Through a tightly regulated, ATP dependent pathway, hepatocytes Frontiers Glutathione: Pharmacological aspects and implications for clinical use in non alcoholic fatty liver disease Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression Nature Communications