Melanosis coli: A comprehensive review Gastroenterologa y Hepatologa (English Edition) Melanosis coli is dark brown black pigmentation of colorectal mucosa associated with chronic use of laxatives containing anthraquinone. Examples of such laxatives include senna and rhubarb derivatives. Clinical Importance: There is no association Figure 2 from Smokers' melanosis in a Nigerian population: Pathology Outlines Melanotic macule
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