Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Aspirin Glutathione peroxidase activity in blood cells from aspirin induced asthma patients aspirin [TUSOM Pharmwiki]
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