Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Glutathione Inj 600 Mg Pinkline Exports Sex differences in glutathione metabolism and acetaminophen toxicity Clinically relevant therapeutic approaches against acetaminophen hepatotoxicity and acute liver failure ScienceDirect