Melanosis Coli El Atlas Gastrointestinal gastrointestinalatlas.com Mucosal melanocytic macules Melanosis coli is dark brown black pigmentation of colorectal mucosa associated with chronic use of laxatives containing anthraquinone. Examples of such laxatives include senna and rhubarb derivatives. Clinical Importance: There is no association Melanotic macules of the tongue in a newborn Journal of the American Academy of Dermatology
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