Fish oil omega 3s. And misunderstanding this distinction is more than just a detail. It's something I see all the time in practice, and it often leads people to take the wrong Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol and Glutathione: Myths Debunked