Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums Acetaminophen C8H9NO2 CID 1983 PubChem Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. USMLE Step 2 CK Question of the Day: Altered Mental State After Over the counter pain reliever and Prescription Hydrocodone acetaminophen Osmosis Blog