Individuals with MTHFR mutations and slow COMT activity can generally take N acetylcysteine (NAC) and glutathione, but there are some important considerations: ## N Acetylcysteine (NAC) * **Benefits**: NAC supports the production of glutathione, N Acetyl Cysteine Berry 150g Powder DID YOU KNOW NAC is a precursor to glutathione, the master antioxidant? This means it boosts your body's natural detox abilities, combats oxidative stress, and promotes overall immune health. Support your body Redox dependent antioxidant mechanisms of NAC. Intracellular GSH is Download Scientific Diagram