Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective Paracetamolinduced hepatotoxicity at recommended dosage Kurtovic 2003 Journal of Internal Medicine Wiley Online Library
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paracetamol and glutathione depletion Myth-busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor - and as moms