Depletion of hepatic glutathione and selective protein oxidation and inhibition of lipogenesis A Literature Review of Glutathione Therapy in Ameliorating Hepatic Dysfunction in Non Alcoholic Fatty Liver Disease Who's talking about this big problem? Low glutathione aa a causative big factor in gallstones. Why? Your biggest detoxification genes are the cytochrome P450 genes. These work very hard in eliminating most Glutathione in Brain: Overview of Its Conformations, Functions, Biochemical Characteristics, Quantitation and Potential Therapeutic Role in Brain Disorders Neurochemical Research Springer Nature Link