Simultaneous Quantification of Multiple Urinary Naphthalene Metabolites by Liquid Chromatography Tandem Mass Spectrometry PLOS One Site of Reactivity Models Predict Molecular Reactivity of Diverse Chemicals with Glutathione S. Joshua Swamidass, MD PhD Glutathione is one of the most important molecules in detoxification. It drives Phase II conjugation and helps neutralize oxidative stress at the cellular level. But detoxification does not end with transformation. It Glutathione Conjugation!