Department of Pathology Lukacs Laboratory Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Histamine and TH2 cytokines regulate the biosynthesis of cysteinyl leukotrienes and expression of their receptors in human mast cells Inflammation Research Springer Nature Link What is Mast Cell Activation Syndrome? Longevity Health