Glucose 6 Phosphate Dehydrogenase Deficiency and Cardiovascular Risk in Familial Hypercholesterolemia: A Retrospective Cohort Study Know About G6PD Deficiency G6PD deficiency is one of the most common inherited metabolic disorders. When triggered, it can lead to haemolytic anaemia, which may cause symptoms such as paleness, Glucose 6 phosphate dehydrogenase (G6PD) deficiency X linked recessive Xq28 is not true recessive as heterozygotes can express the trait; G6PD > No NADPH > No RBC glutathione protection > free radical damage hemolysis DNA damage and synaptic and behavioural disorders in glucose 6 phosphate dehydrogenase deficient mice ScienceDirect