Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Frontiers Acetaminophen induced liver injury: Molecular mechanism and treatments from natural products Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. how acetaminophen is broken down and metabolized! why you should not worry about glutathione depletion! #acetaminophen #glutathione #harvardmed #metabolism #medicine