Sex differences in glutathione metabolism and acetaminophen toxicity 5 6) By contrast, latency I Burkitt B cells were particularly vulnerable to ferroptosis induction by blockade of either cystine import, glutathione synthesis or glutathione peroxidase 4 (GPX4). Eric also found roles for Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis Cell Death & Disease JCI Insight NAD+ precursors prolong survival and improve cardiac phenotypes in a mouse model of Friedreich's Ataxia