Beyond a Measure of Liver FunctionBilirubin Acts as a Potential Cardiovascular Protector in Chronic Kidney Disease Patients Will heavy exercise significantly raise bilirubin levels? Bilirubin metabolism and its application in disease prevention: mechanisms and research advances Inflammation Research Springer Nature Link Bilirubin, a hepatoprotective agent that activates SIRT1, PGC 1, and PPAR , while inhibiting NF B in rats with metabolic associated fatty liver disease Scientific Reports