N Acetyl 4 benzoquinone imine (NAPQI, N Acetyl p benzoquinonimine, CAS Number: 50700 49 7) Cayman Chemical GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Solved The stepwise mechanism below shows how glutathione Chegg.com Acetaminophen (Paracetamol) Toxicity A common and potentially fatal cause of acute liver failure due to toxic accumulation of the metabolite NAPQI when glutathione stores are depleted. Early recognition and timely administration