Frontiers MitochondrialLysosomal Axis in Acetaminophen Hepatotoxicity Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Metabolism of acetaminophen (paracetamol) in plantstwo independent pathways result in the formation of a glutathione and a glucose conjugate Environmental Science and Pollution Research Springer Nature Link Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect