GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Critical Roles of the CysteineGlutathione Axis in the Production of Glutamyl Peptides in the Nervous System Metabolic fate of the natural anticancer agent cucurbitacin B: an LCMS MS enabled profiling of its major phase I and II conjugates in vivo Analytical and Bioanalytical Chemistry Springer Nature Link Metabolic Activation of Mefenamic Acid Leading to Mefenamyl S Acyl Glutathione Adduct Formation In Vitro and In Vivo in Rat Drug Metabolism and Disposition