lCarnitine therapy improves right heart dysfunction through Cpt1dependent fatty acid oxidation Agrawal 2022 Pulmonary Circulation Wiley Online Library Carnitine is an essential cofactor for transport of long chain fatty acids into mitochondria, where oxidation takes place. Carnitine deficiency leads to depressed mitochondrial oxidation of fatty acids, resulting in storage of fat Combined metabolic activators to treat mitochondrial dysfunction Mitochondrial dysfunction is a common feature of many human diseases and is emerging as a therapeutic target. Systems biology and multiomics approaches have revealed that Comprehensive review of the expanding roles of the carnitine pool in metabolic physiology: beyond fatty acid oxidation Journal of Translational Medicine Springer Nature Link