Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Understanding the Impact of Acetaminophen: Tylenol and Glutathione in Autism Do You Reach for Tylenol Often? Whether it's for pain, headaches, or fever Tylenol (acetaminophen) is one of the most commonly used medications. But here's something most people don't realize Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect